Italy Achieves Record Plasma Collection in 2025, Yet Still Falls Short of Self-Sufficiency
According to recent data from the National Blood Centre, Italy has set a new record in plasma collection, with 919.7 tonnes collected in 2025, surpassing the previous year’s total by over 11 tonnes. This milestone is a testament to the dedication of Italy’s millions of voluntary and unpaid blood donors, as well as the efforts of collection centers and associations. However, despite this progress, the country still struggles to meet its demand for blood-derived drugs, particularly immunoglobulins.
Growing Demand for Plasma-Derived Medicines
Professor Luciana Teofili, General Director of the National Blood Center, notes that while the Italian system has demonstrated its ability to exceed planned objectives, self-sufficiency in plasma collection remains a significant challenge. The demand for plasma-derived drugs, especially immunoglobulins, has increased by 57% over the past decade, driven by the growing need for treatments for specific genetic diseases, oncological, neurological, and haematological conditions. Teofili emphasizes that Italy currently covers around 60% of its demand for immunoglobulins, with the remaining share being sourced from the market at significant cost to the National Health Service.
Apheresis Collection: A Key Factor in Plasma Collection Growth
The increase in plasma collection is largely attributed to the growth of apheresis collection, a procedure that allows for the collection of plasma while returning red blood cells and platelets to the donor. This method enables more frequent donations, with some donors able to give as often as every 15 days. In 2025, Italy collected 15.6 kilos of plasma per thousand inhabitants, moving closer to the medium-term objective of 18 kilos per thousand inhabitants, a crucial step towards achieving strategic independence in plasma-derived medicines.
Efforts to Improve Self-Sufficiency and Appropriate Use of Immunoglobulins
To address the ongoing challenge of self-sufficiency, the National Blood Center is working closely with donor associations, such as AVIS, FIDAS, FRATRES, and the Italian Red Cross, to increase plasma collection. Additionally, the Center has launched a study, financed by the National Center for Disease Prevention and Control (CCM) of the Ministry of Health, to evaluate the clinical appropriateness of using immunoglobulins in hospital settings. This study, involving multiple regions and institutions, aims to provide essential tools for monitoring the correct use of these drugs and ultimately contribute to Italy’s goal of self-sufficiency in plasma collection.
A Call to Action for Regular Donations
As Italy continues to strive for self-sufficiency in plasma collection, the importance of regular donations cannot be overstated. Professor Teofili emphasizes the need to convince more people to choose regular donation, particularly through apheresis, to help meet the growing demand for plasma-derived medicines. By supporting this effort, individuals can contribute to the well-being of patients relying on these life-saving treatments.
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